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Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.
Kim, Dong-Gyun; Cho, Sujin; Lee, Kyu-Yeon; Cheon, Seung-Ho; Yoon, Hye-Jin; Lee, Joo-Youn; Kim, Dongyoon; Shin, Kwang-Soo; Koh, Choong-Hyun; Koo, Ji Sung; Choi, Yuri; Lee, Hyung Ho; Oh, Yu-Kyoung; Jeong, Yoo-Seong; Chung, Suk-Jae; Baek, Moonkyu; Jung, Kwan-Young; Lim, Hyo Jin; Kim, Hyoun Sook; Park, Sung Jean; Lee, Jeong-Yeon; Lee, Sang Jae; Lee, Bong-Jin.
Afiliação
  • Kim DG; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Cho S; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Lee KY; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Cheon SH; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Yoon HJ; Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
  • Lee JY; Chemical Data-Driven Research Center, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Kim D; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Shin KS; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Koh CH; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Koo JS; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Choi Y; Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
  • Lee HH; Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
  • Oh YK; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Jeong YS; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Chung SJ; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Baek M; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Jung KY; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Lim HJ; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea.
  • Kim HS; Research Institute, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.
  • Park SJ; Research Institute, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.
  • Lee JY; Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon, 13120, Republic of Korea.
  • Lee SJ; Department of Medicine, College of Medicine, Hanyang University, Seoul, 04763, Republic of Korea.
  • Lee BJ; PAL-XFEL, Pohang Accelerator Laboratory, POSTECH, Pohang, Gyeongbuk, 37673, Republic of Korea. sangjaelee@postech.ac.kr.
Cell Mol Life Sci ; 78(1): 207-225, 2021 Jan.
Article em En | MEDLINE | ID: mdl-32140747
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / 3-Hidroxiesteroide Desidrogenases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / 3-Hidroxiesteroide Desidrogenases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article