Emergence of oxygen- and pyridoxal phosphate-dependent reactions.
FEBS J
; 287(7): 1403-1428, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32142210
ABSTRACT
Pyridoxal 5'-phosphate (PLP) is an organic cofactor employed by ~ 4% of enzymes. The structure of the PLP cofactor allows for the stabilization of carbanions through resonance. A small number of PLP-dependent enzymes employ molecular oxygen as a cosubstrate. Here, we review the biological roles and possible mechanisms of these enzymes, and we observe that these enzymes are found in multiple protein families, suggesting that reaction with oxygen might have emerged de novo in several protein families and thus could be directed to emerge again through laboratory evolution experiments.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Fosfato de Piridoxal
Limite:
Humans
Idioma:
En
Revista:
FEBS J
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá