Perisynaptic schwann cells - The multitasking cells at the developing neuromuscular junctions.
Semin Cell Dev Biol
; 104: 31-38, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32147379
ABSTRACT
Neuromuscular junctions (NMJs) are specialized synapses in the peripheral nervous system that allow the transmission of neuronal impulses to skeletal muscles for their contraction. Due to its size and accessibility, the NMJ is a commonly used model for studying basic principles of synapse organization and function. Similar to synapses in the central nervous system, NMJs are composed of presynaptic axonal terminals, the postsynaptic machinery formed at the membrane of the muscle fibers, and the synapse-associated glial cells. The special glial cells at the NMJs are called terminal Schwann cells or perisynaptic Schwann cells (PSCs). Decades of studies on the NMJ, as well as the most recent discoveries, have revealed multiple functions for PSCs at different stages of synaptic formation, maintenance, and disassembly. This review summarizes major observations in the field.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Células de Schwann
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Terminações Pré-Sinápticas
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Junção Neuromuscular
Limite:
Animals
Idioma:
En
Revista:
Semin Cell Dev Biol
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article