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Guy's cancer cohort - real world evidence for cancer pathways.
Moss, C; Haire, A; Cahill, F; Enting, D; Hughes, S; Smith, D; Sawyer, E; Davies, A; Zylstra, J; Haire, K; Rigg, A; Van Hemelrijck, M.
Afiliação
  • Moss C; King's College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), Guy's Hospital, 3rd Floor Bermondsey Wing, London, SE1 9RT, UK. charlotte.moss@kcl.ac.uk.
  • Haire A; King's College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), Guy's Hospital, 3rd Floor Bermondsey Wing, London, SE1 9RT, UK.
  • Cahill F; King's College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), Guy's Hospital, 3rd Floor Bermondsey Wing, London, SE1 9RT, UK.
  • Enting D; King's College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), Guy's Hospital, 3rd Floor Bermondsey Wing, London, SE1 9RT, UK.
  • Hughes S; Comprehensive Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Smith D; King's College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), Guy's Hospital, 3rd Floor Bermondsey Wing, London, SE1 9RT, UK.
  • Sawyer E; Comprehensive Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Davies A; Comprehensive Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Zylstra J; Comprehensive Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Haire K; Department of Upper Gastrointestinal Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Rigg A; Department of Upper Gastrointestinal Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Van Hemelrijck M; South East London (SEL) Accountable Cancer Network, Guy's and St Thomas' NHS Foundation Trust, London, UK.
BMC Cancer ; 20(1): 187, 2020 Mar 17.
Article em En | MEDLINE | ID: mdl-32178645
BACKGROUND: The burden of disease due to cancer remains substantial. Since the value of real-world evidence has also been recognised by regulatory agencies, we established a Research Ethics Committee (REC) approved research database for cancer patients (Reference: 18/NW/0297). CONSTRUCTION AND CONTENT: Guy's Cancer Cohort introduces the concept of opt-out consent processes for research in a subset of oncology patients diagnosed and treated at a large NHS Trust in the UK. From April 2016 until March 2017, 1388 eligible patients visited Guy's and St Thomas' NHS Foundation Trust (GSTT) for breast cancer management. For urological cancers this number was 1757 and for lung cancer 677. The Cohort consists of a large repository of routinely collected clinical data recorded both retrospectively and prospectively. The database contains detailed clinical information collected at various timepoints across the treatment pathway inclusive of diagnostic data, and data on disease progression, recurrence and survival. CONCLUSIONS: Guy's Cancer Cohort provides a valuable infrastructure to answer a wide variety of research questions of a clinical, mechanistic, and supportive care nature. Clinical research using this database will result in improved patient safety and experience. Guy's Cancer Cohort promotes collaborative research and will accept applications for the release of anonymised datasets for research purposes.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias da Mama / Bases de Dados Factuais / Neoplasias Urológicas / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias da Mama / Bases de Dados Factuais / Neoplasias Urológicas / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article