Hypersensitivities following allergen antigen recognition by unconventional T cells.
Allergy
; 75(10): 2477-2490, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32181878
ABSTRACT
Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and class II molecules and provide anti-microbial and anti-tumour immunity. Conventional T cells have also been implicated in type IV (also termed delayed-type or T cell-mediated) hypersensitivity reactions in response to protein-derived allergen antigens. In addition to conventional T cells, subsets of unconventional T cells exist, which recognise non-protein antigens in the context of monomorphic MHC class I-like molecules. These include T cells that are restricted to the cluster of differentiation 1 (CD1) family members, known as CD1-restricted T cells, and mucosal-associated invariant T cells (MAIT cells) that are restricted to the MHC-related protein 1 (MR1). Compared with conventional T cells, much less is known about the immune functions of unconventional T cells and their role in hypersensitivities. Here, we review allergen antigen presentation by MHC-I-like molecules, their recognition by unconventional T cells, and the potential role of unconventional T cells in hypersensitivities. We also speculate on possible scenarios of allergen antigen presentation by MHC-I-like molecules to unconventional T cells, the hallmarks of such responses, and the expected frequencies of hypersensitivities within the human population.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Células T Invariantes Associadas à Mucosa
/
Hipersensibilidade
Limite:
Humans
Idioma:
En
Revista:
Allergy
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Austrália