Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Article
em En
| MEDLINE
| ID: mdl-32205350
ABSTRACT
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV).
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Antivirais
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Tilorona
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Vírus Chikungunya
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Coronavirus
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Doenças Transmissíveis Emergentes
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Ebolavirus
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Coronavírus da Síndrome Respiratória do Oriente Médio
Limite:
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2020
Tipo de documento:
Article