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The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.
Fage, Christopher D; Lathouwers, Thomas; Vanmeert, Michiel; Gao, Ling-Jie; Vrancken, Kristof; Lammens, Eveline-Marie; Weir, Angus N M; Degroote, Ruben; Cuppens, Harry; Kosol, Simone; Simpson, Thomas J; Crump, Matthew P; Willis, Christine L; Herdewijn, Piet; Lescrinier, Eveline; Lavigne, Rob; Anné, Jozef; Masschelein, Joleen.
Afiliação
  • Fage CD; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
  • Lathouwers T; Laboratory of Gene Technology, KU Leuven, Kasteelpark Arenberg 21, PO Box 2462, 3001, Heverlee, Belgium.
  • Vanmeert M; Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Herestraat 49, PO Box 1041, 3000, Leuven, Belgium.
  • Gao LJ; Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Herestraat 49, PO Box 1041, 3000, Leuven, Belgium.
  • Vrancken K; Laboratory of Molecular Bacteriology, Rega Institute for Medical Research, Herestraat 49, PO Box 1037, 3000, Leuven, Belgium.
  • Lammens EM; Laboratory of Gene Technology, KU Leuven, Kasteelpark Arenberg 21, PO Box 2462, 3001, Heverlee, Belgium.
  • Weir ANM; School of Chemistry, Cantock's Close, University of Bristol, Bristol, BS8 1TS, UK.
  • Degroote R; Laboratory of Gene Technology, KU Leuven, Kasteelpark Arenberg 21, PO Box 2462, 3001, Heverlee, Belgium.
  • Cuppens H; Department of Human Genetics, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
  • Kosol S; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
  • Simpson TJ; School of Chemistry, Cantock's Close, University of Bristol, Bristol, BS8 1TS, UK.
  • Crump MP; School of Chemistry, Cantock's Close, University of Bristol, Bristol, BS8 1TS, UK.
  • Willis CL; School of Chemistry, Cantock's Close, University of Bristol, Bristol, BS8 1TS, UK.
  • Herdewijn P; Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Herestraat 49, PO Box 1041, 3000, Leuven, Belgium.
  • Lescrinier E; Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Herestraat 49, PO Box 1041, 3000, Leuven, Belgium.
  • Lavigne R; Laboratory of Gene Technology, KU Leuven, Kasteelpark Arenberg 21, PO Box 2462, 3001, Heverlee, Belgium.
  • Anné J; Laboratory of Molecular Bacteriology, Rega Institute for Medical Research, Herestraat 49, PO Box 1037, 3000, Leuven, Belgium.
  • Masschelein J; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Angew Chem Int Ed Engl ; 59(26): 10549-10556, 2020 06 22.
Article em En | MEDLINE | ID: mdl-32208550
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Staphylococcus aureus / Inibidores Enzimáticos / Enoil-(Proteína de Transporte de Acila) Redutase (NADPH, B-Específica) / Antibacterianos Tipo de estudo: Prognostic_studies Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Staphylococcus aureus / Inibidores Enzimáticos / Enoil-(Proteína de Transporte de Acila) Redutase (NADPH, B-Específica) / Antibacterianos Tipo de estudo: Prognostic_studies Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido