Effect of moderate to severe atopic dermatitis on the prognosis of egg allergy resolution
Asian Pac J Allergy Immunol
; 41(1): 30-36, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-32247308
ABSTRACT
BACKGROUND:
Few studies have examined the effect of atopic dermatitis (AD) on the resolution of food allergies in Asia, and the predictors of egg allergy resolution are not yet well defined.OBJECTIVE:
We evaluated whether AD severity could predict the resolution of egg allergy.METHODS:
This retrospective cohort study included infants under 24 months of age diagnosed with IgE-mediated egg white allergy. We included subjects who completed a 60-month follow-up. Open oral food challenges (OFCs) and serologic tests were performed at the time of initial diagnosis and at 36 ± 3 and 60 ± 3 months.RESULTS:
We analyzed 68 patients (39 boys and 29 girls). OFCs were performed in 88.2% of the patients. The egg allergy remission rates were 23.5% and 47.1% by 3 and by 5 years of age, respectively. Persistent egg allergy was significantly associated with moderate to severe AD and house dust mite sensitization. Kaplan-Meier curve analysis revealed that patients with moderate to severe AD had higher persistent egg allergy rates than patients with no and mild AD (p = 0.012). Multivariable analysis identified moderate to severe AD as strongly associated with persistent egg allergy (p = 0.001).CONCLUSIONS:
In this study, 47.1% of infants had resolved egg white allergies at 60 months. Moderate to severe AD may be a practical and important prognostic factor for persistent egg allergy in clinical settings.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Hipersensibilidade a Ovo
/
Dermatite Atópica
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
2023
Tipo de documento:
Article