Engineering photoluminescent and magnetic lamellar hydroxyapatite by facile one-step Se/Gd dual-doping.
J Mater Chem B
; 6(21): 3515-3521, 2018 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-32254446
ABSTRACT
The design and synthesis of multifunctional hydroxyapatite (HAp) nanoparticles are important in expanding their clinical applications. Herein we report a novel selenium (Se) and gadolinium (Gd) dual-doped lamellar hydroxyapatite (L-HAp-Se-Gd) produced by facile one-step template-assisted synthesis. The results show that the as-prepared L-HAp-Se-Gd nanoparticles exhibit obvious changes in morphology, dimensions, and crystallinity as compared to bare L-HAp. XRD results reveal that high dopant levels of Se and Gd reduce the degree of ordering of HAp lamellae. It is found that the L-HAp-Se-Gd nanoparticles display Gd content-dependent blue fluorescence under ultraviolet (UV) irradiation and magnetic properties. Cell tests with mouse embryo osteoblast cells (MC3T3-E1) reveal their improved biocompatibility over bare L-HAp due to Se incorporation. These results indicate that L-HAp-Se-Gd nanoparticles have potential in numerous applications such as multifunctional gene delivery and bioimaging.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
J Mater Chem B
Ano de publicação:
2018
Tipo de documento:
Article