Crystal Structure of the Ergothioneine Sulfoxide Synthase from <i>Candidatus Chloracidobacterium thermophilum</i> and Structure-Guided Engineering To Modulate Its Substrate Selectivity.

Naowarojna, Nathchar; Irani, Seema; Hu, Weiyao; Cheng, Ronghai; Zhang, Li; Li, Xinhao; Chen, Jiesheng; Zhang, Yan Jessie; Liu, Pinghua

Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering To Modulate Its Substrate Selectivity.

Naowarojna, Nathchar; Irani, Seema; Hu, Weiyao; Cheng, Ronghai; Zhang, Li; Li, Xinhao; Chen, Jiesheng; Zhang, Yan Jessie; Liu, Pinghua.

Afiliação

Naowarojna N; Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Irani S; Department of Molecular Biosciences and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, United States.
Hu W; Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Cheng R; School of Chemistry and Chemical Engineering, Shanghai JiaoTong University, Shanghai 200240, China.
Zhang L; Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Li X; Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Chen J; School of Chemistry and Chemical Engineering, Shanghai JiaoTong University, Shanghai 200240, China.
Zhang YJ; School of Chemistry and Chemical Engineering, Shanghai JiaoTong University, Shanghai 200240, China.
Liu P; Department of Molecular Biosciences and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, United States.

ACS Catal ; 9(8): 6955-6961, 2019 Aug 02.

Article em En | MEDLINE | ID: mdl-32257583

Palavras-chave

Rosetta Enzyme Design; enzyme engineering; ergothioneine; nonheme iron enzyme; sulfur-containing natural product

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: ACS Catal Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos