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Health and Economic Impact of Routine Pediatric Pneumococcal Immunization Programs in Canada: A Retrospective Analysis.
Wilson, Michele R; Wasserman, Matthew D; Breton, Marie-Claude; Peloquin, Francois; Earnshaw, Stephanie R; McDade, Cheryl; Sings, Heather L; Farkouh, Raymond A.
Afiliação
  • Wilson MR; RTI Health Solutions, Research Triangle Park, NC, USA.
  • Wasserman MD; Pfizer, Inc, New York, NY, USA. Matt.Wasserman@pfizer.com.
  • Breton MC; Pfizer Canada ULC, Kirkland, QC, Canada.
  • Peloquin F; Pfizer Canada ULC, Kirkland, QC, Canada.
  • Earnshaw SR; RTI Health Solutions, Research Triangle Park, NC, USA.
  • McDade C; RTI Health Solutions, Research Triangle Park, NC, USA.
  • Sings HL; Pfizer, Inc, Collegeville, PA, USA.
  • Farkouh RA; Pfizer, Inc, Collegeville, PA, USA.
Infect Dis Ther ; 9(2): 341-353, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32270372
OBJECTIVE: A model was developed to estimate the historical impact (including total societal health and economic benefit) of pneumococcal conjugate vaccine (PCV) programs in the overall Canadian population between 2005 and 2015, inclusively. METHODS: Historical incidence of invasive pneumococcal disease (IPD), pneumonia, and acute otitis media (AOM) were obtained from epidemiologic databases supplemented with published and unpublished data. Two scenarios were considered: (1) the observed historical incidence from 2005 to 2015 in the setting of PCV use; (2) a hypothetical scenario in which we estimated the number of disease cases assuming no PCV use. Disease cases averted as a result of PCV programs were calculated by subtracting the number of observed historical cases from the number of estimated cases expected in the absence of PCV use. RESULTS: PCV programs were estimated to have saved 6631 lives and averted 14,990 IPD cases, 735,700 pneumonia episodes, and 3,697,993 AOM episodes. Positive clinical outcomes resulted in total cost savings of CAD $1.76 billion over 11 years. Vaccination costs were offset by the direct medical cost savings from fewer cases of IPD, pneumonia, and AOM. CONCLUSIONS: Canadian PCV programs have provided significant health benefits and resulted in a substantial value for money. Net savings achieved over the reviewed period would have provided funding for $1.76 billion in other health care costs or public health initiatives. These findings highlight the importance of considering the total value of a vaccination program, rather than vaccine acquisition costs only, when assessing the value of immunization programs.
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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Infect Dis Ther Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Infect Dis Ther Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos