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A multicenter, randomized, placebo-controlled, double-blind phase 3 trial with open-arm comparison indicates safety and efficacy of nephroprotective therapy with ramipril in children with Alport's syndrome.
Gross, Oliver; Tönshoff, Burkhard; Weber, Lutz T; Pape, Lars; Latta, Kay; Fehrenbach, Henry; Lange-Sperandio, Baerbel; Zappel, Hildegard; Hoyer, Peter; Staude, Hagen; König, Sabine; John, Ulrike; Gellermann, Jutta; Hoppe, Bernd; Galiano, Matthias; Hoecker, Britta; Ehren, Rasmus; Lerch, Christian; Kashtan, Clifford E; Harden, Markus; Boeckhaus, Jan; Friede, Tim.
Afiliação
  • Gross O; Clinic for Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany. Electronic address: gross.oliver@med.uni-goettingen.de.
  • Tönshoff B; Department of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.
  • Weber LT; Pediatric Nephrology, Children`s and Adolescents` Hospital, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
  • Pape L; Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
  • Latta K; Clementine Kinderhospital Frankfurt, Frankfurt, Germany.
  • Fehrenbach H; Pediatric Nephrology, Children's Hospital, Memmingen, Germany.
  • Lange-Sperandio B; Dr. v. Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.
  • Zappel H; Clinic of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, Göttingen, Germany.
  • Hoyer P; Pediatric Nephrology, Pediatrics II, University of Duisburg-Essen, Essen, Germany.
  • Staude H; Pediatric Nephrology, University Children's Hospital Rostock, Rostock, Germany.
  • König S; University Children's Hospital Münster, Münster, Germany.
  • John U; Division of Pediatric Nephrology, University Children's Hospital, Jena, Germany.
  • Gellermann J; Pediatric Nephrology, Charité Children's Hospital, Berlin, Germany.
  • Hoppe B; Division of Pediatric Nephrology, Department of Pediatrics, University of Bonn, Bonn, Germany.
  • Galiano M; Department of Pediatrics and Adolescent Medicine, University Hospital, Friedrich-Alexander-University Erlangen, Erlangen, Germany.
  • Hoecker B; Department of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.
  • Ehren R; Pediatric Nephrology, Children`s and Adolescents` Hospital, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
  • Lerch C; Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
  • Kashtan CE; Department of Pediatrics, Division of Nephrology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • Harden M; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.
  • Boeckhaus J; Clinic for Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.
  • Friede T; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.
Kidney Int ; 97(6): 1275-1286, 2020 06.
Article em En | MEDLINE | ID: mdl-32299679
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ramipril / Nefrite Hereditária Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: Kidney Int Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ramipril / Nefrite Hereditária Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: Kidney Int Ano de publicação: 2020 Tipo de documento: Article