[Immunophenotypic Analysis of Patients with Adult Acute T-Lymphoblastic Leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 28(2): 442-445, 2020 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-32319376
ABSTRACT
OBJECTIVE:
To analyze the results of immunophenotyping in patients with acute T-lymphoblastic leukemia (T-ALL) so as to improve the understanding of early T-cell precursor acute T-lymphoblastic leukemia (ETP-ALL) and near ETP-ALL with elevated CD5.METHODS:
The results of immunophenotypes in 62 patients with newly diagnosed adult T-ALL in our hospital were retrospectively analyzed. According to the expression of CD5, CD1a, CD8 and My/S antigens, the patients were divided into 3 groups ETP, near ETP and non-ETP. The immunophenotypic characteristics and basic clinical data of three groups were compared and analyzed.RESULTS:
There were significant differences in age, white blood cell and plt counts as well as percentage of bone marrow blasts among three groups (Pï¼0.05). ETP and near ETP mainly belonged to Pro T and pre T, and non-ETP mainly belonged to cortical T and mature T. The positive rates of My/S, CD1a, CD8 and CD5 were significantly different among three groups (Pï¼0.01). The positive rates of CD4 and CD3 in non-ETP group were significantly higher than those in ETP and near-ETP group (Pï¼0.01). The positive rate of CD56 in near-ETP group was 50%, which was significantly higher than that in ETP group (16.7%) and non-ETP group (0%) (Pï¼0.01).CONCLUSION:
According to the expression of CD5, CD1a, CD8 and My/S antigens, T-ALL patients can be divided into three groups ETP, near ETP and non ETP, the immunophenotypes and basic clinical data among 3 groups are statistically different.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Leucemia-Linfoma Linfoblástico de Células T Precursoras
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
Idioma:
Zh
Revista:
Zhongguo Shi Yan Xue Ye Xue Za Zhi
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China