Shedding light into the black box: Advances in in vitro systems for studying implantation.
Dev Biol
; 463(1): 1-10, 2020 07 01.
Article
em En
| MEDLINE
| ID: mdl-32360630
ABSTRACT
Implantation represents a critical step for embryonic development and pregnancy. Its success depends on the complex interplay between a receptive endometrium and a competent embryo. Implantation-related events remain hardly accessible, making implantation a true "black box" in developmental biology. Improved in vitro models are becoming useful experimental tools, as they are considerably more accessible than in vivo models, easier to manipulate, and permit the use of human cells or tissues, thus increasing the translational value of the studies. In this Review, we briefly summarize the relevant cell types and structures involved into the process of implantation, in order to outline which compartments are indispensable for creating the perfect in vitro model. We also critically address advantages and limitations of available models and assess their application potential. Moreover, we examine the chances and challenges brought by the latest approaches to recapitulate the endometrial compartment, as well as by peri-implantational embryoids.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
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Endométrio
Limite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha