Whole Genome DNA Methylation Analysis of Active Pulmonary Tuberculosis Disease Identifies Novel Epigenotypes: PARP9/miR-505/RASGRP4/GNG12 Gene Methylation and Clinical Phenotypes.

Chen, Yung-Che; Hsiao, Chang-Chun; Chen, Ting-Wen; Wu, Chao-Chien; Chao, Tung-Ying; Leung, Sum-Yee; Eng, Hock-Liew; Lee, Chiu-Ping; Wang, Ting-Ya; Lin, Meng-Chih

Whole Genome DNA Methylation Analysis of Active Pulmonary Tuberculosis Disease Identifies Novel Epigenotypes: PARP9/miR-505/RASGRP4/GNG12 Gene Methylation and Clinical Phenotypes.

Chen, Yung-Che; Hsiao, Chang-Chun; Chen, Ting-Wen; Wu, Chao-Chien; Chao, Tung-Ying; Leung, Sum-Yee; Eng, Hock-Liew; Lee, Chiu-Ping; Wang, Ting-Ya; Lin, Meng-Chih.

Afiliação

Chen YC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Hsiao CC; Graduate Institute of Clinical Medical Sciences and Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Chen TW; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Wu CC; Graduate Institute of Clinical Medical Sciences and Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Chao TY; Molecular Medicine Research Center, and Bioinformatics Center, Chang Gung University, Taoyuan 33302, Taiwan.
Leung SY; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 30068, Taiwan.
Eng HL; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30068, Taiwan.
Lee CP; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Chiao Tung University, Hsinchu 30068, Taiwan.
Wang TY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Lin MC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Int J Mol Sci ; 21(9)2020 Apr 30.

Article em En | MEDLINE | ID: mdl-32365959

Assuntos

Metilação de DNA/fisiologia; Regiões Promotoras Genéticas/genética; Tuberculose Pulmonar/genética; Estudos de Coortes; Metilação de DNA/genética; Proteína Forkhead Box O3/genética; Subunidades gama da Proteína de Ligação ao GTP/genética; Humanos; Proteínas de Membrana/genética; Proteínas de Neoplasias/genética; Proteínas de Ligação a Fosfato/genética; Poli(ADP-Ribose) Polimerases/genética; Proteína Regulatória Associada a mTOR/genética; Fatores ras de Troca de Nucleotídeo Guanina/genética

Palavras-chave

GNG12; PARP9; RASGRP4; miR505; pulmonary TB; whole genome DNA methylation

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Regiões Promotoras Genéticas / Metilação de DNA Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Taiwan

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