Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice.

Turconi, Giorgio; Kopra, Jaakko; Võikar, Vootele; Kulesskaya, Natalia; Vilenius, Carolina; Piepponen, T Petteri; Andressoo, Jaan-Olle

Turconi, Giorgio; Kopra, Jaakko; Võikar, Vootele; Kulesskaya, Natalia; Vilenius, Carolina; Piepponen, T Petteri; Andressoo, Jaan-Olle.

Afiliação

Turconi G; Department of Pharmacology, Faculty of Medicine and Helsinki Institute of Life Science, Haartmaninkatu 8, University of Helsinki, Helsinki 00014, Finland.
Kopra J; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikinkaari 5E, University of Helsinki, Helsinki 00014, Finland.
Võikar V; Neuroscience Center/Laboratory Animal Center, Mustialankatu 1, University of Helsinki, Helsinki 00014, Finland.
Kulesskaya N; Neuroscience Center/Laboratory Animal Center, Mustialankatu 1, University of Helsinki, Helsinki 00014, Finland.
Vilenius C; Institute of Biotechnology, Viikinkaari 5D, University of Helsinki, Helsinki 00014, Finland.
Piepponen TP; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikinkaari 5E, University of Helsinki, Helsinki 00014, Finland.
Andressoo JO; Department of Pharmacology, Faculty of Medicine and Helsinki Institute of Life Science, Haartmaninkatu 8, University of Helsinki, Helsinki 00014, Finland.

Mol Ther Methods Clin Dev ; 17: 831-842, 2020 Jun 12.

Article em En | MEDLINE | ID: mdl-32368564

Palavras-chave

GDNF; dopamine system; long-term side effects; motor function; safety evaluation

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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Ther Methods Clin Dev Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Finlândia

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