Genotoxic potential of a novel PDE-4B inhibitor Apremilast by chromosomal aberration and micronucleus assay in mice.

Afzal, Muhammad; Kazmi, Imran; Alharbi, Khalid Saad; Quazi, Anwarulabedin Mohsin; Nadeem, Muhammad Shahid; Alotaibi, Nasser Hadal; Alruwaili, Nabil K; Anwar, Firoz; Alenezi, Sattam Khulaif; Al-Sanea, Mohammad M

Afzal, Muhammad; Kazmi, Imran; Alharbi, Khalid Saad; Quazi, Anwarulabedin Mohsin; Nadeem, Muhammad Shahid; Alotaibi, Nasser Hadal; Alruwaili, Nabil K; Anwar, Firoz; Alenezi, Sattam Khulaif; Al-Sanea, Mohammad M.

Afiliação

Afzal M; Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah-72341, Saudi Arabia.
Kazmi I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, P.O. Box: 80200, Zip Code: 21589, Jeddah, Saudi Arabia.
Alharbi KS; Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah-72341, Saudi Arabia.
Quazi AM; Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah-72341, Saudi Arabia.
Nadeem MS; Department of Biochemistry, Faculty of Science, King Abdulaziz University, P.O. Box: 80200, Zip Code: 21589, Jeddah, Saudi Arabia.
Alotaibi NH; Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakakah-72341, Saudi Arabia.
Ameeduzzafar; Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia-72341.
Alruwaili NK; Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia-72341.
Anwar F; Department of Biochemistry, Faculty of Science, King Abdulaziz University, P.O. Box: 80200, Zip Code: 21589, Jeddah, Saudi Arabia.
Alenezi SK; Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Unaizah City, Qassim region-5888, Saudi Arabia.
Al-Sanea MM; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakakah-72341, Saudi Arabia.

Saudi Pharm J ; 28(5): 615-620, 2020 May.

Article em En | MEDLINE | ID: mdl-32435143

Palavras-chave

Apremilast; Chromosomal aberration; Cyclophosphamide; Genetic damage; Genotoxicity; Mice

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Saudi Pharm J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Arábia Saudita