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Blocking integrin α4ß7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.
Rai, Ravi P; Liu, Yunshan; Iyer, Smita S; Liu, Silvia; Gupta, Biki; Desai, Chirayu; Kumar, Pradeep; Smith, Tekla; Singhi, Aatur D; Nusrat, Asma; Parkos, Charles A; Monga, Satdarshan P; Czaja, Mark J; Anania, Frank A; Raeman, Reben.
Afiliação
  • Rai RP; Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Liu Y; Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.
  • Iyer SS; Center for Comparative Medicine, School of Veterinary Medicine, University of California, Davis, CA, USA; California National Primate Research Center, University of California, Davis, CA, USA; Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA, USA.
  • Liu S; Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • Gupta B; Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Desai C; Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Gujarat, India.
  • Kumar P; Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.
  • Smith T; Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.
  • Singhi AD; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA; Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Nusrat A; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Parkos CA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Monga SP; Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School
  • Czaja MJ; Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.
  • Anania FA; Division of Gastroenterology and Inborn Error Products, Food and Drug Administration, Silver Spring, MD, USA.
  • Raeman R; Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: reben.raeman@pitt.edu.
J Hepatol ; 73(5): 1013-1022, 2020 11.
Article em En | MEDLINE | ID: mdl-32540177
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Integrinas / Hepatopatia Gordurosa não Alcoólica / Dieta Ocidental / Mucosa Intestinal / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Integrinas / Hepatopatia Gordurosa não Alcoólica / Dieta Ocidental / Mucosa Intestinal / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos