Combinatorial Resurfacing of Dengue Envelope Protein Domain III Antigens Selectively Ablates Epitopes Associated with Serotype-Specific or Infection-Enhancing Antibody Responses.

Remmel, Jennifer L; Beauchemin, Kathryn S; Mishra, Akaash K; Frei, Julia C; Lai, Jonathan R; Bailey-Kellogg, Chris; Ackerman, Margaret E

Remmel, Jennifer L; Beauchemin, Kathryn S; Mishra, Akaash K; Frei, Julia C; Lai, Jonathan R; Bailey-Kellogg, Chris; Ackerman, Margaret E.

Afiliação

Remmel JL; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.
Beauchemin KS; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755, United States.
Mishra AK; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755, United States.
Frei JC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Bailey-Kellogg C; Department of Computer Science, Dartmouth College, Hanover, New Hampshire 03755, United States.
Ackerman ME; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.

ACS Comb Sci ; 22(9): 446-456, 2020 09 14.

Article em En | MEDLINE | ID: mdl-32574486

Assuntos

Anticorpos Antivirais/química; Antígenos Virais/química; Vírus da Dengue/química; Epitopos/química; Proteínas do Envelope Viral/química; Anticorpos Antivirais/imunologia; Reações Antígeno-Anticorpo; Antígenos Virais/imunologia; Vírus da Dengue/imunologia; Epitopos/imunologia; Proteínas do Envelope Viral/imunologia

Palavras-chave

directed evolution; epitope-focusing; immunogen design; protein resurfacing; saturation mutagenesis; yeast surface display

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Vírus da Dengue / Anticorpos Antivirais / Epitopos / Antígenos Virais Tipo de estudo: Risk_factors_studies Idioma: En Revista: ACS Comb Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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