Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis.

Gamboa, Jorge L; Roshanravan, Baback; Towse, Theodore; Keller, Chad A; Falck, Aaron M; Yu, Chang; Frontera, Walter R; Brown, Nancy J; Ikizler, T Alp

Gamboa, Jorge L; Roshanravan, Baback; Towse, Theodore; Keller, Chad A; Falck, Aaron M; Yu, Chang; Frontera, Walter R; Brown, Nancy J; Ikizler, T Alp.

Afiliação

Gamboa JL; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Roshanravan B; Division of Nephrology, Department of Medicine, University of California, Davis, California.
Towse T; Department of Biomedical Sciences, Grand Valley State University, Allendale, Michigan.
Keller CA; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Falck AM; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Yu C; Department of Biostatics, Vanderbilt University Medical Center, Nashville, Tennessee.
Frontera WR; Department of Physical Medicine, Rehabilitation, and Sports Medicine, University of Puerto Rico, San Juan, Puerto Rico.
Brown NJ; Department of Physiology and Biophysics, University of Puerto Rico, San Juan, Puerto Rico.
Ikizler TA; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Clin J Am Soc Nephrol ; 15(7): 926-936, 2020 07 01.

Article em En | MEDLINE | ID: mdl-32591419

Assuntos

Mitocôndrias/fisiologia; Músculo Quadríceps/diagnóstico por imagem; Músculo Quadríceps/fisiopatologia; Insuficiência Renal Crônica/fisiopatologia; Insuficiência Renal Crônica/terapia; Tecido Adiposo/diagnóstico por imagem; Adulto; Idoso; Dinaminas/metabolismo; Feminino; Taxa de Filtração Glomerular; Humanos; Imageamento por Ressonância Magnética; Espectroscopia de Ressonância Magnética; Masculino; Pessoa de Meia-Idade; Força Muscular; Fosfocreatina/metabolismo; Desempenho Físico Funcional; Músculo Quadríceps/patologia; Diálise Renal; Índice de Gravidade de Doença; Teste de Caminhada

Palavras-chave

Chronic; Chronic inflammation; DNM1L protein; Frailty; Inflammation; Magnetic Resonance Spectroscopy; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Muscle; Phosphocreatine; Phosphorus; Renal Insufficiency; Sarcopenia; Skeletal; Skeletal muscle; Walk Test; chronic kidney disease; hemodialysis; human; mitochondria; oxidative stress

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Músculo Quadríceps / Insuficiência Renal Crônica / Mitocôndrias Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin J Am Soc Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2020 Tipo de documento: Article

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