Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome.
J Exp Med
; 217(10)2020 10 05.
Article
em En
| MEDLINE
| ID: mdl-32603407
ABSTRACT
In response to T cell-dependent antigens, mature B cells are stimulated to form germinal centers (GCs), the sites of B cell affinity maturation and the cell of origin (COO) of most B cell lymphomas. To explore the dynamics of GC B cell development beyond the known dark zone and light zone compartments, we performed single-cell (sc) transcriptomic analysis on human GC B cells and identified multiple functionally linked subpopulations, including the distinct precursors of memory B cells and plasma cells. The gene expression signatures associated with these GC subpopulations were effective in providing a sc-COO for â¼80% of diffuse large B cell lymphomas (DLBCLs) and identified novel prognostic subgroups of DLBCL.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Centro Germinativo
/
Linfoma
Limite:
Humans
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2020
Tipo de documento:
Article