Current Advances in Drug Delivery Systems for Capsule Endoscopy.
Curr Drug Metab
; 21(11): 838-843, 2020.
Article
em En
| MEDLINE
| ID: mdl-32682365
ABSTRACT
BACKGROUND:
Oral administration of medications and current oral modified-release systems are the most preferred drug delivery routes, but they provide efficacy up to 12-24 hours per administration and are not useful when the patient has short transit time. The once-daily administered formulations are the endpoint of many types of drug development, and some innovations in capsule endoscopy (CE) can solve this problem.OBJECTIVE:
This review aims to reveal recent advances in drug delivery systems (DDS) for CE as an essential field of research for more precise drug targeting at the gastrointestinal (GI) tract.METHODS:
We performed a narrative overview of the MEDLINE database from 1991-2020 using the keywords of DDS and CE with synthesizing the findings, hand searches, and authoritative articles.RESULTS:
There are microelectromechanical systems and non-mechanical patent technologies for DDS for CE, and the implementation of wireless-capsule medical devices into the human body will provide new diagnostic and therapeutic options. Integrating biomedical CE with DDS and the cloud technology will bring remote real-time feedbackbased automated treatment or responsive medication.CONCLUSION:
Swallowable drug delivery systems for capsule endoscopy brings an entirely new approach for diagnostic and therapeutic methods in digestive diseases.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Endoscopia por Cápsula
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Drug Metab
Assunto da revista:
METABOLISMO
/
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Bulgária