CRISPR-Cas12a with an oAd Induces Precise and Cancer-Specific Genomic Reprogramming of EGFR and Efficient Tumor Regression.

Yoon, A-Rum; Jung, Bo-Kyeong; Choi, Eunyoung; Chung, Eugene; Hong, JinWoo; Kim, Jin-Soo; Koo, Taeyoung; Yun, Chae-Ok

Yoon, A-Rum; Jung, Bo-Kyeong; Choi, Eunyoung; Chung, Eugene; Hong, JinWoo; Kim, Jin-Soo; Koo, Taeyoung; Yun, Chae-Ok.

Afiliação

Yoon AR; Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea; Institute of Nano Science and Technology (INST), Hanyang University, Seoul 04763, Republic of Korea.
Jung BK; Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea.
Choi E; Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Chung E; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea.
Hong J; Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea; GeneMedicine Co., Ltd., Seoul 04763, Republic of Korea.
Kim JS; Institute for Basic Science (IBS), Daejeon 34126, Republic of Korea. Electronic address: jskim01@snu.ac.kr.
Koo T; Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: taeyoungkoo@khu.ac.kr.
Yun CO; Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea; Institute of Nano Science and Technology (INST), Hanyang University, Seoul 04763, Republic of Korea; GeneMedicine Co., Ltd., Seoul 04763, Republic of Korea. Electronic address: chaeok@hanyang.ac

Mol Ther ; 28(10): 2286-2296, 2020 10 07.

Article em En | MEDLINE | ID: mdl-32682455

Assuntos

Sistemas CRISPR-Cas; Receptores ErbB/genética; Edição de Genes; Vetores Genéticos/genética; Terapia Viral Oncolítica; Vírus Oncolíticos/genética; RNA Guia de Cinetoplastídeos/genética; Humanos; Neoplasias/genética; Neoplasias/terapia

Palavras-chave

CRISPR; Cas12a; Cpf1; EGFR; anti-tumor effect; genome editing; oncolytic virus; out-of-frame

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: RNA Guia de Cinetoplastídeos / Vírus Oncolíticos / Terapia Viral Oncolítica / Sistemas CRISPR-Cas / Receptores ErbB / Edição de Genes / Vetores Genéticos Limite: Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2020 Tipo de documento: Article

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