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Modified expression of vitamin D receptor and CYP27B1 in denervation-induced muscle atrophy.
Mori, Risako; Yokokawa, Takumi; Fujita, Satoshi.
Afiliação
  • Mori R; Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
  • Yokokawa T; Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, Japan.
  • Fujita S; Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan. Electronic address: safujita@fc.ritsumei.ac.jp.
Biochem Biophys Res Commun ; 529(3): 733-739, 2020 08 27.
Article em En | MEDLINE | ID: mdl-32736700
The vitamin D pathway is related to the mass and function of skeletal muscles. Several studies have demonstrated the role of vitamin D receptor (VDR) and CYP27B1 in skeletal muscles, suggesting that these proteins may regulate skeletal muscles and their function. However, it remains unclear whether the expression of VDR and CYP27B1 is modified in skeletal muscle atrophy. We investigated whether denervation-induced muscle atrophy is associated with altered expression of VDR and CYP27B1 in murine skeletal muscles. Skeletal muscles were excised from C57BL/6J mice, 3 and 7 days after the mice underwent denervation surgery. Denervation induced muscle atrophy and enhanced the expression of MuRF1 and Atrogin-1 in the gastrocnemius and soleus. The protein expression of VDR was increased in the denervated gastrocnemius; in contrast, denervation decreased the protein expression of CYP27B1 in the gastrocnemius and soleus. These results suggest that denervation-induced muscle atrophy is associated with changes in the expression of vitamin D-related proteins in murine skeletal muscles.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Atrofia Muscular / Receptores de Calcitriol / 25-Hidroxivitamina D3 1-alfa-Hidroxilase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Atrofia Muscular / Receptores de Calcitriol / 25-Hidroxivitamina D3 1-alfa-Hidroxilase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão