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The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells.
Kwesi-Maliepaard, Eliza Mari; Aslam, Muhammad Assad; Alemdehy, Mir Farshid; van den Brand, Teun; McLean, Chelsea; Vlaming, Hanneke; van Welsem, Tibor; Korthout, Tessy; Lancini, Cesare; Hendriks, Sjoerd; Ahrends, Tomasz; van Dinther, Dieke; den Haan, Joke M M; Borst, Jannie; de Wit, Elzo; van Leeuwen, Fred; Jacobs, Heinz.
Afiliação
  • Kwesi-Maliepaard EM; Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Aslam MA; Division of Tumor Biology and Immunology, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Alemdehy MF; Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, 60800 Multan, Pakistan.
  • van den Brand T; Division of Tumor Biology and Immunology, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • McLean C; Division of Gene Regulation, Oncode Institute, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Vlaming H; Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • van Welsem T; Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Korthout T; Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Lancini C; Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Hendriks S; Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Ahrends T; Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • van Dinther D; Division of Tumor Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • den Haan JMM; Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, 1081HV Amsterdam, The Netherlands.
  • Borst J; Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, 1081HV Amsterdam, The Netherlands.
  • de Wit E; Division of Tumor Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • van Leeuwen F; Division of Gene Regulation, Oncode Institute, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Jacobs H; Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands; fred.v.leeuwen@nki.nl h.jacobs@nki.nl.
Proc Natl Acad Sci U S A ; 117(34): 20706-20716, 2020 08 25.
Article em En | MEDLINE | ID: mdl-32764145

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Histona-Lisina N-Metiltransferase / Linfócitos T CD8-Positivos Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Histona-Lisina N-Metiltransferase / Linfócitos T CD8-Positivos Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda