The influence of multiple oral administration on the pharmacokinetics and distribution profile of dalcetrapib in rats.

Takubo, Hiroaki; Ishikawa, Tomohiro; Taniguchi, Toshio; Iwanaga, Kazunori; Nomura, Yukihiro

Takubo, Hiroaki; Ishikawa, Tomohiro; Taniguchi, Toshio; Iwanaga, Kazunori; Nomura, Yukihiro.

Afiliação

Takubo H; Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan.
Ishikawa T; Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan.
Taniguchi T; Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan.
Iwanaga K; Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan.
Nomura Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan.

Xenobiotica ; 51(1): 82-87, 2021 Jan.

Article em En | MEDLINE | ID: mdl-32783571

Assuntos

Anticolesterolemiantes/farmacocinética; Compostos de Sulfidrila/farmacocinética; Administração Oral; Amidas; Animais; Anticolesterolemiantes/administração & dosagem; Proteínas de Transferência de Ésteres de Colesterol; Ésteres; Humanos; Masculino; Ratos; Compostos de Sulfidrila/administração & dosagem

Palavras-chave

CETP; Dalcetrapib; JTT-705; RO4607381; covalent binding; mixed disulfide; pharmacokinetics

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Compostos de Sulfidrila / Anticolesterolemiantes Limite: Animals / Humans / Male Idioma: En Revista: Xenobiotica Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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