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Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
Limbocker, Ryan; Mannini, Benedetta; Ruggeri, Francesco S; Cascella, Roberta; Xu, Catherine K; Perni, Michele; Chia, Sean; Chen, Serene W; Habchi, Johnny; Bigi, Alessandra; Kreiser, Ryan P; Wright, Aidan K; Albright, J Alex; Kartanas, Tadas; Kumita, Janet R; Cremades, Nunilo; Zasloff, Michael; Cecchi, Cristina; Knowles, Tuomas P J; Chiti, Fabrizio; Vendruscolo, Michele; Dobson, Christopher M.
Afiliação
  • Limbocker R; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Mannini B; Department of Chemistry and Life Science, United States Military Academy, West Point, NY, 10996, USA.
  • Ruggeri FS; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Cascella R; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Xu CK; Department of Experimental and Clinical Biomedical Science, University of Florence, 50134, Florence, Italy.
  • Perni M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Chia S; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Chen SW; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Habchi J; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Bigi A; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Kreiser RP; Department of Experimental and Clinical Biomedical Science, University of Florence, 50134, Florence, Italy.
  • Wright AK; Department of Chemistry and Life Science, United States Military Academy, West Point, NY, 10996, USA.
  • Albright JA; Department of Chemistry and Life Science, United States Military Academy, West Point, NY, 10996, USA.
  • Kartanas T; Department of Chemistry and Life Science, United States Military Academy, West Point, NY, 10996, USA.
  • Kumita JR; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Cremades N; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Zasloff M; Institute for Biocomputation and Physics of Complex Systems (BIFI)-Joint Unit BIFI-IQFR (CSIC), University of Zaragoza, 50018, Zaragoza, Spain.
  • Cecchi C; MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC, 20010, USA.
  • Knowles TPJ; Department of Experimental and Clinical Biomedical Science, University of Florence, 50134, Florence, Italy.
  • Chiti F; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
  • Vendruscolo M; Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, CB3 0HE, UK.
  • Dobson CM; Department of Experimental and Clinical Biomedical Science, University of Florence, 50134, Florence, Italy. fabrizio.chiti@unifi.it.
Commun Biol ; 3(1): 435, 2020 08 13.
Article em En | MEDLINE | ID: mdl-32792544
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Espermina / Membrana Celular / Colestanos / Dobramento de Proteína / Multimerização Proteica Limite: Humans Idioma: En Revista: Commun Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Espermina / Membrana Celular / Colestanos / Dobramento de Proteína / Multimerização Proteica Limite: Humans Idioma: En Revista: Commun Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido