Galectin-1 is inversely associated with type 2 diabetes independently of obesity - A SCAPIS pilot study.
Metabol Open
; 4: 100017, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-32812946
ABSTRACT
OBJECTIVES:
Galectin-1 is a recently discovered adipokine that increases with obesity and increased energy intake in adipose tissue. Our aim was to assess whether serum galectin-1 is associated with type 2 diabetes (T2D) and other parameters of the metabolic syndrome independently of body mass index (BMI) in a cohort from the general population.METHODS:
In this cross-sectional population-based cohort study from the western part of Sweden, we investigated associations between serum galectin-1, clinical characteristics and inflammatory markers in 989 women and men aged 50-65 years [part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot cohort].RESULTS:
We showed in linear models that serum galectin-1 was independently and (1) inversely associated with T2D (pâ¯<â¯0.05) and glucose (pâ¯<â¯0.05); and (2) positively associated with age (pâ¯<â¯0.01), sex (pâ¯<â¯0.01), BMI (pâ¯<â¯0.01), insulin (pâ¯<â¯0.01) and C-reactive protein (pâ¯<â¯0.01). Furthermore, galectin-1 demonstrated univariate correlations with triglycerides (râ¯=â¯0.20, pâ¯<â¯0.01), homeostasis model assessment for insulin resistance (râ¯=â¯0.24, pâ¯<â¯0.01), tumor necrosis factor-α (râ¯=â¯0.24, pâ¯<â¯0.01), interleukin-6 (IL-6; râ¯=â¯0.20, pâ¯<â¯0.01) and HbA1c (râ¯=â¯0.14, pâ¯<â¯0.01).CONCLUSION:
In a cross-sectional study of a middle-aged population, we showed that serum galectin-1 is (1) inversely associated with T2D independently of BMI; and (2) independently associated with other markers of the metabolic syndrome These results warrant prospective and functional studies on the role of galectin-1 in T2D.
ALAT, alanine aminotransferase; BMI, body mass index; CRP, C-reactive protein; Cross-sectional; ELISA, electrochemiluminescence immunoassay; Galectin-1; HDL, high-density lipoprotein; HOMA, homeostasis model assessment; IFN-γ, interferon gamma; IL, interleukin; LDL, low-density lipoprotein; MSD, Meso Scale Diagnostics; Metabolic syndrome; Obesity; SCAPIS, Swedish CArdioPulmonary bioImage Study; SEM, standard error of the mean; Sex; T2D, type 2 diabetes; TNF-α, tumor necrosis factor-α; Type 2 diabetes
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Bases de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Metabol Open
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Suécia