Orchestration of signaling by structural disorder in class 1 cytokine receptors.
Cell Commun Signal
; 18(1): 132, 2020 08 24.
Article
em En
| MEDLINE
| ID: mdl-32831102
ABSTRACT
BACKGROUND:
Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the inside of cells. Remarkably, they orchestrate key biological processes such as proliferation, differentiation, immunity and growth through long disordered intracellular domains (ICDs), but without having intrinsic kinase activity. Despite these key roles, their characteristics remain rudimentarily understood.METHODS:
The current paper asks the question of why disorder has evolved to govern signaling of C1CRs by reviewing the literature in combination with new sequence and biophysical analyses of chain properties across the family.RESULTS:
We uncover that the C1CR-ICDs are fully disordered and brimming with SLiMs. Many of these short linear motifs (SLiMs) are overlapping, jointly signifying a complex regulation of interactions, including network rewiring by isoforms. The C1CR-ICDs have unique properties that distinguish them from most IDPs and we forward the perception that the C1CR-ICDs are far from simple strings with constitutively bound kinases. Rather, they carry both organizational and operational features left uncovered within their disorder, including mechanisms and complexities of regulatory functions.CONCLUSIONS:
Critically, the understanding of the fascinating ability of these long, completely disordered chains to orchestrate complex cellular signaling pathways is still in its infancy, and we urge a perceptional shift away from the current simplistic view towards uncovering their full functionalities and potential. Video abstract.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Receptores de Citocinas
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Proteínas Intrinsicamente Desordenadas
Limite:
Humans
Idioma:
En
Revista:
Cell Commun Signal
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Dinamarca