Relationship between treatment center case volume and survival for localized Ewing sarcoma: The role of radiotherapy timing.
Pediatr Blood Cancer
; 67(11): e28685, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32881378
ABSTRACT
In the treatment of localized Ewing sarcoma (EWS), delays in local therapy are known to adversely impact overall survival (OS). However, the role of treatment center volume in EWS outcomes, and the interaction between center volume and local therapy timing with definitive radiotherapy, remains unknown. Using the National Cancer Database, we demonstrate that treatment at the lowest EWS volume centers is associated with reduced OS, explained partly by higher rates of delayed local therapy. Treatment at the highest volume centers results in improved OS, but appears independent of radiotherapy timing. Future efforts to improve care for EWS patients across treatment centers are imperative.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Radioterapia
/
Sarcoma de Ewing
/
Neoplasias Ósseas
/
Planejamento da Radioterapia Assistida por Computador
/
Institutos de Câncer
/
Hospitais com Alto Volume de Atendimentos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Pediatr Blood Cancer
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2020
Tipo de documento:
Article