A pair of new isocoumarin enantiomers of Ludwigia hyssopifolia.
Nat Prod Res
; 36(7): 1749-1756, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-32883111
ABSTRACT
A pair of new isocoumarin derivative enantiomers, (S)-(-)-3-(3,3-dichloro-2-hydroxy-propyl)-4-chlorine-6,8-dihydroxy-isochromen-1- one (1a) and (R)-(+)-3-(3,3-dichloro-2-hydroxy-propyl)-4-chlorine-6,8-dihydroxy-isochromen-1- one (1 b), as well as seven known compounds (2-8) were isolated from Ludwigia hyssopifolia. Compounds 1a and 1 b were confirmed to be a pair of enantiomers by chiral HPLC-CD analysis, and the structure of compound 1 was determined by spectroscopic analyses including extensive 1 D (1H NMR, 13C NMR) and 2 D NMR spectra (COSY, HSQC and HMBC) and MS data. And the absolute configurations of compounds 1a and 1 b were determined by the quantum chemical ECD calculations. Compounds 2-8 are firstly reported from this plant. In the in vitro assays, compounds 5 and 8 can inhibit human laryngeal cancer Hep-2 cell line growth in a dose- and time-dependent manner. In addition, compounds 2 and 4 have effects on increasing glucose uptake in vitro. Compound 2 showed a strong glucose uptake in L6 cells, with enhancements by 1.8 folds.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Onagraceae
/
Isocumarinas
Limite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China