Fast repetitive stretch suppresses denervation-induced muscle fibrosis.
Muscle Nerve
; 62(6): 746-756, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32893367
ABSTRACT
BACKGROUND:
We aimed to examine the influence of different speeds of stretching on denervation-induced skeletal muscle fibrosis.METHODS:
Stretching was passively applied to rat plantaris muscle denervated by sciatic nerve excision in three different cycles of 0.5, 3, or 12 cycles/min, for 20 min/d for 2 weeks.RESULTS:
Gene analysis results showed greater expression of fibrosis-related factors with fast stretching compared with non-stretched muscle. Laser Doppler blood flow analysis indicated reduced intramuscular blood flow during stretching. Histological analysis demonstrated fibrotic area decreases in 12 cycles/min stretched muscle compared with non-stretched muscle.CONCLUSIONS:
Slower stretching induced greater mRNA expression of collagen and fibroblasts and greater decrement of blood flow. Histologically, faster stretching suppressed fibrosis. These results suggest that fast repetitive stretching of denervated muscle might suppress processes of muscle fibrosis.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Nervo Isquiático
/
Fibrose
/
Músculo Esquelético
/
Exercícios de Alongamento Muscular
/
Fibroblastos
/
Denervação Muscular
Limite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão