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A Cellular Mechanism to Detect and Alleviate Reductive Stress.
Manford, Andrew G; Rodríguez-Pérez, Fernando; Shih, Karen Y; Shi, Zhuo; Berdan, Charles A; Choe, Mangyu; Titov, Denis V; Nomura, Daniel K; Rape, Michael.
Afiliação
  • Manford AG; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA.
  • Rodríguez-Pérez F; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley CA 94720, USA.
  • Shih KY; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley CA 94720, USA.
  • Shi Z; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA.
  • Berdan CA; Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley CA 94720, USA.
  • Choe M; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley CA 94720, USA; Center for Computational Biology, University of California at Berkeley, Berkeley CA
  • Titov DV; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley CA 94720, USA; Center for Computational Biology, University of California at Berkeley, Berkeley CA
  • Nomura DK; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley CA 94720, USA; Department of Chemistry, University of California at Berkeley, CA 94720, USA.
  • Rape M; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley CA 94720, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkel
Cell ; 183(1): 46-61.e21, 2020 10 01.
Article em En | MEDLINE | ID: mdl-32941802
ABSTRACT
Metazoan organisms rely on conserved stress response pathways to alleviate adverse conditions and preserve cellular integrity. Stress responses are particularly important in stem cells that provide lifetime support for tissue formation and repair, but how these protective systems are integrated into developmental programs is poorly understood. Here we used myoblast differentiation to identify the E3 ligase CUL2FEM1B and its substrate FNIP1 as core components of the reductive stress response. Reductive stress, as caused by prolonged antioxidant signaling or mitochondrial inactivity, reverts the oxidation of invariant Cys residues in FNIP1 and allows CUL2FEM1B to recognize its target. The ensuing proteasomal degradation of FNIP1 restores mitochondrial activity to preserve redox homeostasis and stem cell integrity. The reductive stress response is therefore built around a ubiquitin-dependent rheostat that tunes mitochondrial activity to redox needs and implicates metabolic control in coordination of stress and developmental signaling.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas de Transporte / Espécies Reativas de Oxigênio / Estresse Oxidativo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas de Transporte / Espécies Reativas de Oxigênio / Estresse Oxidativo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos