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The role of lifestyle and non-modifiable risk factors in the development of metabolic disturbances from childhood to adolescence.
Börnhorst, Claudia; Russo, Paola; Veidebaum, Toomas; Tornaritis, Michael; Molnár, Dénes; Lissner, Lauren; Mårild, Staffan; De Henauw, Stefaan; Moreno, Luis A; Floegel, Anna; Ahrens, Wolfgang; Wolters, Maike.
Afiliação
  • Börnhorst C; Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359, Bremen, Germany.
  • Russo P; Institute of Food Sciences, National Research Council, 83100, Avellino, Italy.
  • Veidebaum T; National Institute for Health Development, Estonian Centre of Behavioral and Health Sciences, 11619, Tallinn, Estonia.
  • Tornaritis M; Research and Education Institute of Child Health, 2035, Strovolos, Cyprus.
  • Molnár D; Department of Pediatrics, Medical School, University of Pécs, 7623, Pécs, Hungary.
  • Lissner L; Section for Epidemiology and Social Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530, Gothenburg, Sweden.
  • Mårild S; Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, 41685, Gothenburg, Sweden.
  • De Henauw S; Department of Public Health, Ghent University, 9000, Ghent, Belgium.
  • Moreno LA; GENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, Universidad de Zaragoza, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nu
  • Floegel A; Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359, Bremen, Germany.
  • Ahrens W; Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359, Bremen, Germany.
  • Wolters M; Institute of Statistics, Faculty of Mathematics and Computer Science, University of Bremen, 28359, Bremen, Germany.
Int J Obes (Lond) ; 44(11): 2236-2245, 2020 11.
Article em En | MEDLINE | ID: mdl-32943762
ABSTRACT

BACKGROUND:

The study aimed to identify the effects of lifestyle, C-reactive protein (CRP) and non-modifiable risk factors on metabolic disturbances in the transition from childhood to adolescence.

METHODS:

In 3889 children of the IDEFICS/I.Family cohort, latent transition analysis was applied to estimate probabilities of metabolic disturbances based on waist circumference, blood pressure, blood glucose, and lipids assessed at baseline and at 2- and 6-year follow-ups. Multivariate mixed-effects models were used to assess the age-dependent associations of lifestyle, non-modifiable risk factors and CRP, with the transformed probabilities of showing abdominal obesity, hypertension, dyslipidemia, or several metabolic disturbances (reference being metabolically healthy).

RESULTS:

Higher maternal body mass index, familial hypertension as well as higher CRP z-score increased the risk for all four metabolic outcomes while low/medium parental education increased the risk of abdominal obesity and of showing several metabolic disturbances. Out of the lifestyle factors, the number of media in the bedroom, membership in a sports club, and well-being were associated with some of the outcomes. For instance, having at least one media in the bedroom increased the risk for showing several metabolic disturbances where the odds ratio (OR) markedly increased with age (1.30 [95% confidence interval 1.18; 1.43] at age 8; 1.18 [1.14; 1.23] for interaction with age; i.e., resulting in an OR of 1.30 × 1.18 = 1.53 at age 9 and so forth). Further, entering puberty at an early age was strongly associated with the risk of abdominal obesity (2.43 [1.60; 3.69] at age 8; 0.75 [0.69; 0.81] for interaction with age) and the risk of showing several metabolic disturbances (2.46 [1.53; 3.96] at age 8; 0.71 [0.65; 0.77] for interaction with age).

CONCLUSIONS:

Various factors influence the metabolic risk of children revealing the need for multifactorial interventions. Specifically, removing media from children's bedroom as well as membership in a sports club seem to be promising targets for prevention.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Obesidade Infantil / Estilo de Vida / Doenças Metabólicas Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Int J Obes (Lond) Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Obesidade Infantil / Estilo de Vida / Doenças Metabólicas Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Int J Obes (Lond) Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha