JNK signalling regulates antioxidant responses in neurons.
Redox Biol
; 37: 101712, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32949970
ABSTRACT
Reactive oxygen species (ROS) are generated during physiological bouts of synaptic activity and as a consequence of pathological conditions in the central nervous system. How neurons respond to and distinguish between ROS in these different contexts is currently unknown. In Drosophila mutants with enhanced JNK activity, lower levels of ROS are observed and these animals are resistant to both changes in ROS and changes in synapse morphology induced by oxidative stress. In wild type flies, disrupting JNK-AP-1 signalling perturbs redox homeostasis suggesting JNK activity positively regulates neuronal antioxidant defense. We validated this hypothesis in mammalian neurons, finding that JNK activity regulates the expression of the antioxidant gene Srxn-1, in a c-Jun dependent manner. We describe a conserved 'adaptive' role for neuronal JNK in the maintenance of redox homeostasis that is relevant to several neurodegenerative diseases.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Proteínas Quinases JNK Ativadas por Mitógeno
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Redox Biol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido