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Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults.
Takeuchi, Hikaru; Tomita, Hiroaki; Browne, Ryan; Taki, Yasuyuki; Kikuchi, Yoshie; Ono, Chiaki; Yu, Zhiqian; Nouchi, Rui; Yokoyama, Ryoichi; Kotozaki, Yuka; Nakagawa, Seishu; Sekiguchi, Atsushi; Iizuka, Kunio; Hanawa, Sugiko; Araki, Tsuyoshi; Miyauchi, Carlos Makoto; Sakaki, Kohei; Nozawa, Takayuki; Ikeda, Shigeyuki; Yokota, Susumu; Magistro, Daniele; Sassa, Yuko; Kawashima, Ryuta.
Afiliação
  • Takeuchi H; Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
  • Tomita H; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
  • Browne R; Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, Japan.
  • Taki Y; Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
  • Kikuchi Y; Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8575, Japan.
  • Ono C; Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
  • Yu Z; Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, Japan.
  • Nouchi R; Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, Japan.
  • Yokoyama R; Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, Japan.
  • Kotozaki Y; Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
  • Nakagawa S; Department of Cognitive Health Science, IDAC, Tohoku University, Sendai 980-8575, Japan.
  • Sekiguchi A; Smart Aging Research Center, Tohoku University, Sendai 980-8575, Japan.
  • Iizuka K; School of Medicine, Kobe University, Kobe 650-0017, Japan.
  • Hanawa S; Division of Clinical research, Medical-Industry Translational Research Center, Fukushima Medical University School of Medicine, Fukushima 960-1925, Japan.
  • Araki T; Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
  • Miyauchi CM; Division of Psychiatry, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, Japan.
  • Sakaki K; Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8575, Japan.
  • Nozawa T; Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8553, Japan.
  • Ikeda S; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
  • Yokota S; Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
  • Magistro D; ADVANTAGE Risk Management Co., Ltd. , Tokyo 153-0051, Japan.
  • Sassa Y; Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
  • Kawashima R; Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Cereb Cortex ; 31(1): 672-680, 2021 01 01.
Article em En | MEDLINE | ID: mdl-32954402
ABSTRACT
The APOE ɛ4 allele is associated with a risk of Alzheimer's disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex-genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex-genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Comportamento / Fatores Sexuais / Apolipoproteína E4 / Substância Branca Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Comportamento / Fatores Sexuais / Apolipoproteína E4 / Substância Branca Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão