Oxidative stress as a key feature of autoimmune thyroiditis: an update.
Minerva Endocrinol
; 45(4): 326-344, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-32969631
ABSTRACT
INTRODUCTION:
Oxidative stress has been proposed as one of the factors concurring in the pathophysiology of autoimmune thyroid diseases. Reactive oxygen species are the main expression of oxidative stress in biological systems, and their production can overcome antioxidant defenses ultimately leading to cell damage, apoptosis, and death. The present review was aimed at describing the state of the art of the relationships between oxidative stress and autoimmune thyroiditis. The most used biomarkers of oxidative stress and their correlation with thyroid function are reported. EVIDENCE ACQUISITION We conducted a search of the literature in the English language starting from 2000, using the following search terms "Hashimoto thyroiditis," "autoimmune thyroiditis," "hypothyroidism," "hyperthyroidism," "oxidative stress," "oxidants," "antioxidant," "advanced glycation end products." Both clinical studies and animal models were evaluated. EVIDENCESYNTHESIS:
Data form clinical studies clearly indicate that the balance between oxidants and antioxidants is shifted towards the oxidative side in patients with autoimmune thyroiditis, suggesting that oxidative stress may be a key event in the pathophysiology of the disease, irrespective of thyroid function. Studies in animal models, such as the NOD.H2h4 mouse, confirm that thyroidal accumulation of ROS plays a role in the initiation and progression of autoimmune thyroiditis.CONCLUSIONS:
Oxidant/antioxidant imbalance represent a key feature of thyroid autoimmunity. Oxidative stress parameters could be used as biochemical markers of chronic inflammation, to better predict the disease evolution along its natural history. Dietary habits and antioxidant supplements may provide protection from autoimmunity, opening new perspectives in the development of more tailored therapies.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Tireoidite Autoimune
/
Estresse Oxidativo
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Minerva Endocrinol
Ano de publicação:
2020
Tipo de documento:
Article