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Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type.
Matsuse, Dai; Yamasaki, Ryo; Maimaitijiang, Guzailiayi; Yamaguchi, Hiroo; Masaki, Katsuhisa; Isobe, Noriko; Matsushita, Takuya; Kira, Jun-Ichi.
Afiliação
  • Matsuse D; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: matsuse@neuro.med.kyushu-u.ac.jp.
  • Yamasaki R; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: ryoya@neuro.med.kyushu-u.ac.jp.
  • Maimaitijiang G; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: maimai@neuro.med.kyushu-u.ac.jp.
  • Yamaguchi H; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: yhiroo@neuro.med.kyushu-u.ac.jp.
  • Masaki K; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  • Isobe N; Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: kuroki@neuro.med.kyushu-u.ac.jp.
  • Matsushita T; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: matusita@neuro.med.kyushu-u.ac.jp.
  • Kira JI; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Translational Neuroscience Center, Graduate School of Medicine, and School of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Ookawa,
J Neuroimmunol ; 349: 577395, 2020 12 15.
Article em En | MEDLINE | ID: mdl-32977251
ABSTRACT
To identify biomarkers for multiple system atrophy-cerebellar type (MSA-C), we used flow cytometry to measure surface marker expression of peripheral blood monocytes from patients with MSA-C or hereditary spinocerebellar degeneration (hSCD) and from healthy controls (HCs). The percentage of intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs and showed significant positive correlations with disease duration and unified MSA rating scale scores. The percentage of CD62L+ intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs. Early decrease of peripheral blood intermediate monocytes is characteristic of MSA-C and is a biomarker.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Monócitos / Cerebelo / Atrofia de Múltiplos Sistemas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Monócitos / Cerebelo / Atrofia de Múltiplos Sistemas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Ano de publicação: 2020 Tipo de documento: Article