Ribosome profiling of HEK293T cells overexpressing codon optimized coagulation factor IX.

Alexaki, Aikaterini; Kames, Jacob; Hettiarachchi, Gaya K; Athey, John C; Katneni, Upendra K; Hunt, Ryan C; Hamasaki-Katagiri, Nobuko; Holcomb, David D; DiCuccio, Michael; Bar, Haim; Komar, Anton A; Kimchi-Sarfaty, Chava

Alexaki, Aikaterini; Kames, Jacob; Hettiarachchi, Gaya K; Athey, John C; Katneni, Upendra K; Hunt, Ryan C; Hamasaki-Katagiri, Nobuko; Holcomb, David D; DiCuccio, Michael; Bar, Haim; Komar, Anton A; Kimchi-Sarfaty, Chava.

Afiliação

Alexaki A; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.
Kames J; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.
Hettiarachchi GK; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.
Athey JC; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.
Katneni UK; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.
Hunt RC; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.
Hamasaki-Katagiri N; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.
Holcomb DD; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.
DiCuccio M; National Center of Biotechnology Information, National Institutes of Health, USA, Bethesda, MD, 20892, USA.
Bar H; Department of Statistics, University of Connecticut, Storrs, CT, 06269, USA.
Komar AA; Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 44115, USA.
Kimchi-Sarfaty C; Center for Biologics Evaluation and Research, Food and Drug Administration, USA, Silver Spring, MD, 20993, USA.

F1000Res ; 9: 174, 2020.

Article em En | MEDLINE | ID: mdl-33014344

Assuntos

Códon/genética; Fator IX/genética; Biossíntese de Proteínas; Ribossomos/genética; Células HEK293; Humanos

Palavras-chave

RNA-seq; Ribo-seq; Ribosome profiling; codon optimization; codon pair usage; codon usage; protein therapeutics; translation kinetics

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ribossomos / Biossíntese de Proteínas / Códon / Fator IX Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: F1000Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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