Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection.
Vet Res
; 51(1): 132, 2020 Oct 17.
Article
em En
| MEDLINE
| ID: mdl-33069243
ABSTRACT
MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Doenças das Aves Domésticas
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Galinhas
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Regulação da Expressão Gênica
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MicroRNAs
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Vírus da Influenza A Subtipo H9N2
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Influenza Aviária
Limite:
Animals
Idioma:
En
Revista:
Vet Res
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China