Bufalin inhibits human diffuse large B-cell lymphoma tumorigenesis by inducing cell death through the Ca2+/NFATC1/cMYC pathway.

Song, Jincheng; Zou, Dan; Zhao, Xiaoxuan; Chen, Yang; Lv, Fei; Wang, Song; Sui, Dan; Han, Qiuyue; Yang, Chunjiao; Wang, Ximing; Liu, Bofang; Deng, Mingming; Zhang, Ye

Song, Jincheng; Zou, Dan; Zhao, Xiaoxuan; Chen, Yang; Lv, Fei; Wang, Song; Sui, Dan; Han, Qiuyue; Yang, Chunjiao; Wang, Ximing; Liu, Bofang; Deng, Mingming; Zhang, Ye.

Afiliação

Song J; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Zou D; Department of Lymphoma, Lymphoma and Myeloma Diagnosis and Treatment Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, PR China.
Zhao X; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Chen Y; Department of Dermatology, Dalian Dermatosis Hospital, Dalian, Liaoning, PR China.
Lv F; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Wang S; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Sui D; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Han Q; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Yang C; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Wang X; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Liu B; The First Laboratory of Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Deng M; Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
Zhang Y; Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University, Shenyang, PR China.

Carcinogenesis ; 42(2): 303-314, 2021 02 25.

Article em En | MEDLINE | ID: mdl-33124657

Assuntos

Antineoplásicos/farmacologia; Bufanolídeos/farmacologia; Sinalização do Cálcio/efeitos dos fármacos; Linfoma Difuso de Grandes Células B/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos; Animais; Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Apoptose/genética; Bufanolídeos/uso terapêutico; Sinalização do Cálcio/genética; Carcinogênese/efeitos dos fármacos; Carcinogênese/genética; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/genética; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Técnicas de Silenciamento de Genes; Humanos; Linfoma Difuso de Grandes Células B/patologia; Masculino; Camundongos; Fatores de Transcrição NFATC/genética; Fatores de Transcrição NFATC/metabolismo; Proteínas Proto-Oncogênicas c-myc/metabolismo; Transdução de Sinais/genética; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Bufanolídeos / Transdução de Sinais / Linfoma Difuso de Grandes Células B / Sinalização do Cálcio / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Carcinogenesis Ano de publicação: 2021 Tipo de documento: Article

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