Non-Invasive Measurement of Drug and 2-HG Signals Using <sup>19</sup>F and <sup>1</sup>H MR Spectroscopy in Brain Tumors Treated with the Mutant IDH1 Inhibitor BAY1436032.

Wenger, Katharina J; Richter, Christian; Burger, Michael C; Urban, Hans; Kaulfuss, Stefan; Harter, Patrick N; Sreeramulu, Sridhar; Schwalbe, Harald; Steinbach, Joachim P; Hattingen, Elke; Bähr, Oliver; Pilatus, Ulrich

Non-Invasive Measurement of Drug and 2-HG Signals Using ¹⁹F and ¹H MR Spectroscopy in Brain Tumors Treated with the Mutant IDH1 Inhibitor BAY1436032.

Wenger, Katharina J; Richter, Christian; Burger, Michael C; Urban, Hans; Kaulfuss, Stefan; Harter, Patrick N; Sreeramulu, Sridhar; Schwalbe, Harald; Steinbach, Joachim P; Hattingen, Elke; Bähr, Oliver; Pilatus, Ulrich.

Afiliação

Wenger KJ; Institute of Neuroradiology, University Hospital Frankfurt, 60528 Frankfurt am Main, Germany.
Richter C; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, 60590 Frankfurt am Main, Germany.
Burger MC; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, 60590 Frankfurt am Main, Germany.
Urban H; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University, 60438 Frankfurt am Main, Germany.
Kaulfuss S; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, 60590 Frankfurt am Main, Germany.
Harter PN; Department of Neurooncology, University Hospital Frankfurt, 60528 Frankfurt am Main, Germany.
Sreeramulu S; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, 60590 Frankfurt am Main, Germany.
Schwalbe H; Department of Neurooncology, University Hospital Frankfurt, 60528 Frankfurt am Main, Germany.
Steinbach JP; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.
Hattingen E; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, 60590 Frankfurt am Main, Germany.
Bähr O; Neuropathological Institute (Edinger-Institute), University Hospital Frankfurt, 60528 Frankfurt am Main, Germany.
Pilatus U; Frankfurt Cancer Institute (FCI), 60596 Frankfurt am Main, Germany.

Cancers (Basel) ; 12(11)2020 Oct 29.

Article em En | MEDLINE | ID: mdl-33138036

Palavras-chave

19F MR spectroscopy; 1H MR spectroscopy; 2-hydroxyglutarate; IDH mutation; IDH1 inhibitor; glioma; murine model; small molecule inhibitor; targeted therapy

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha