Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations.
J Autism Dev Disord
; 51(9): 3365-3373, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-33175317
ABSTRACT
Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Comportamento Autodestrutivo
/
Transtorno do Espectro Autista
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Autism Dev Disord
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos