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Progression of Rebound-Associated Vertebral Fractures Following Denosumab Discontinuation Despite Reinstitution of Treatment: Suppressing Increased Bone Turnover May Not Be Enough.
Anastasilakis, Athanasios D; Trovas, Georgios; Balanika, Alexia; Polyzos, Stergios A; Makras, Polyzois; Tournis, Symeon.
Afiliação
  • Anastasilakis AD; Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece. Electronic address: a.anastasilakis@gmail.com.
  • Trovas G; Laboratory for the Research of Musculoskeletal System "Th. Garofalidis," Medical School, National and Kapodistrian University of Athens, KAT Hospital, Greece.
  • Balanika A; Department of Computed Tomography, Asklepeion Voulas Hospital, Athens, Greece.
  • Polyzos SA; First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Makras P; Department of Endocrinology and Diabetes and Department of Medical Research, 251 Hellenic Airforce and VA Hospital, Athens, Greece.
  • Tournis S; Laboratory for the Research of Musculoskeletal System "Th. Garofalidis," Medical School, National and Kapodistrian University of Athens, KAT Hospital, Greece.
J Clin Densitom ; 24(2): 338-340, 2021.
Article em En | MEDLINE | ID: mdl-33218880
Rebound-associated vertebral fractures (RAVFs) could occur in a minority of the patients who discontinue denosumab. In such patients, denosumab is often reinstituted to rapidly suppress bone turnover and avert the risk of additional fractures. Herein we report the cases of 2 patients who sustained RAVFs, and in whom resuming denosumab treatment did not avert the occurrence of new RAVFs a few months later, despite the suppression of bone turnover markers. It seems that denosumab reinstitution cannot completely eliminate the risk of new RAVFs and that the rebound of bone turnover may not be the sole mechanism to explain this phenomenon.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Osteoporose Pós-Menopausa / Fraturas da Coluna Vertebral / Conservadores da Densidade Óssea Tipo de estudo: Risk_factors_studies Limite: Female / Humans Idioma: En Revista: J Clin Densitom Assunto da revista: ORTOPEDIA Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Osteoporose Pós-Menopausa / Fraturas da Coluna Vertebral / Conservadores da Densidade Óssea Tipo de estudo: Risk_factors_studies Limite: Female / Humans Idioma: En Revista: J Clin Densitom Assunto da revista: ORTOPEDIA Ano de publicação: 2021 Tipo de documento: Article