Clinical application of personalized medicine: heart failure with preserved left ventricular ejection fraction.
Eur Heart J Suppl
; 22(Suppl L): L124-L128, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-33239986
ABSTRACT
Heart failure (HF) with preserved left ventricular (LV) ejection fraction (HFpEF) represent today the largest 'unmet medical need', because none of the drugs presently available improved survival in this consistent proportion of patients with HF, â¼50% of the total, who have an LV ejection fraction ≥50%. Heart failure with preserved left ventricular ejection fraction is a clinical syndrome that in its classical form, is associated to typical risk factors and comorbidities. The comorbidities represent one of the element contributing to the extreme heterogeneity which characterizes HFpEF. The pathophysiological mechanisms, as well as the clinical presentation, are multifaceted. These factors explain, by and large, the failure of a generalized therapeutic strategy, while build the argument for personalized medicine, designed to address the specific phenotypes, with therapies proven in specific subgroups of patients with HFpEF to reduce mortality and improve 'surrogate' outcomes, such as quality of life.
Texto completo:
1
Bases de dados:
MEDLINE
Idioma:
En
Revista:
Eur Heart J Suppl
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália