IRF7 suppresses hematopoietic regeneration under stress via CXCR4.
Stem Cells
; 39(2): 183-195, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33252829
ABSTRACT
Hematopoietic stem cells (HSCs) maintain quiescence under steady state; however, they are compelled to proliferate and expand to replenish the blood system under stress. The molecular basis underlying stress hematopoiesis remains to be fully understood. In this study, we reported that IRF7 represents an important regulator of stress hematopoiesis. Interferon regulatory factor 7 (IRF7) was dispensable for normal hematopoiesis, whereas its deficiency significantly enhanced hematopoietic stem and progenitor cells (HSPCs) regeneration and improved long-term repopulation of HSCs under stress. Mechanistic studies showed that CXCR4 was identified as a downstream target of IRF7. Overexpression of CXCR4 abrogated the enhanced proliferation and regeneration of IRF7-deficient HSPCs under stress. Similar results were obtained in HSCs from human umbilical cord blood. These observations demonstrated that IRF7 plays an important role in hematopoietic regeneration under stress.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
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Receptores CXCR4
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Transplante de Células-Tronco de Sangue do Cordão Umbilical
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Fator Regulador 7 de Interferon
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Hematopoese
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Stem Cells
Ano de publicação:
2021
Tipo de documento:
Article