Multifaceted roles of long non-coding RNAs in triple-negative breast cancer: biology and clinical applications.
Biochem Soc Trans
; 48(6): 2791-2810, 2020 12 18.
Article
em En
| MEDLINE
| ID: mdl-33258920
ABSTRACT
Triple-negative breast cancer (TNBC) is a heterogeneous breast cancer subtype that lacks targeted therapy due to the absence of estrogen, progesterone, and HER2 receptors. Moreover, TNBC was shown to have a poor prognosis, since it involves aggressive phenotypes that confer significant hindrance to therapeutic treatments. Recent state-of-the-art sequencing technologies have shed light on several long non-coding RNAs (lncRNAs), previously thought to have no biological function and were considered as genomic junk. LncRNAs are involved in various physiological as well as pathological conditions, and play a key role in drug resistance, gene expression, and epigenetic regulation. This review mainly focuses on exploring the multifunctional roles of candidate lncRNAs, and their strong association with TNBC development. We also summarise various emerging research findings that establish novel paradigms of lncRNAs function as oncogenes and/or tumor suppressors in TNBC development, suggesting their role as prospective therapeutic targets.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Cromatina
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Regulação Neoplásica da Expressão Gênica
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Apoptose
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Resistencia a Medicamentos Antineoplásicos
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Epigênese Genética
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Neoplasias de Mama Triplo Negativas
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Mutação
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Invasividade Neoplásica
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Índia