Iatrogenic severe hyperglycemia due to parenteral administration of glucose in children - a case series.
Ital J Pediatr
; 46(1): 179, 2020 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-33261643
ABSTRACT
BACKGROUND:
Iatrogenic severe hyperglycemia (ISH) caused by glucose-containing i.v. solution is a potentially fatal treatment error. The objective of this study was to investigate the causes, circumstances, course of disease, and complications of ISH > 300 mg/dl (16.7 mmol/l) in neonates and children.METHODS:
We emailed a survey to 105 neonatal and pediatric intensive care units in Germany, Austria, and Switzerland, asking to retrospectively report cases of ISH.RESULTS:
We received 11 reports about premature infants to children. Four patients (36%) had pooroutcome:
2 died and 2 suffered persistent sequelae. The highest observed blood glucose was at median 983 mg/dl (54.6 mmol/l) (range 594-2240 mg/dl; 33.0-124.3 mmol/l) and median time to normoglycemia was 7 h (range 2-23). Blood glucose was higher and time to normoglycemia longer in patients with poor outcome. Invasive therapy was required in 73% (mechanical ventilation) and 50% (vasopressor therapy) of patients, respectively. Administration of insulin did not differ between outcome groups. Patients with poor outcome showed coma (100% vs. 40%) and seizures (75% vs. 29%) more frequently than those with good outcome.CONCLUSIONS:
ISH is a severe condition with high morbidity and mortality. Further research to amplify the understanding of this condition is needed, but focus should largely be held on its prevention.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Edulcorantes
/
Glucose
/
Hiperglicemia
/
Doença Iatrogênica
/
Infusões Parenterais
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Infant
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Male
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Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
Ital J Pediatr
Assunto da revista:
PEDIATRIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha