mTORC1 Overactivation Leads to Abnormalities in Skeletal Development.

Iwahashi, Sayuki; Tokumura, Kazuya; Park, Gyujin; Ochiai, Shinsuke; Okayama, Yasuka; Fusawa, Hiroki; Ohta, Kaname; Fukasawa, Kazuya; Iezaki, Takashi; Hinoi, Eiichi

Iwahashi, Sayuki; Tokumura, Kazuya; Park, Gyujin; Ochiai, Shinsuke; Okayama, Yasuka; Fusawa, Hiroki; Ohta, Kaname; Fukasawa, Kazuya; Iezaki, Takashi; Hinoi, Eiichi.

Afiliação

Iwahashi S; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Tokumura K; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Park G; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Ochiai S; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Okayama Y; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Fusawa H; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Ohta K; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Fukasawa K; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Iezaki T; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.
Hinoi E; Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University.

Biol Pharm Bull ; 43(12): 1983-1986, 2020.

Article em En | MEDLINE | ID: mdl-33268720

Assuntos

Desenvolvimento Ósseo/fisiologia; Condrócitos/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Proteína 1 do Complexo Esclerose Tuberosa/deficiência; Animais; Alvo Mecanístico do Complexo 1 de Rapamicina/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Proteína 1 do Complexo Esclerose Tuberosa/genética

Palavras-chave

mechanistic/mammalian target of rapamycin complex-1 (mTORC1); skeletogenesis; tuberous sclerosis complex 1; undifferentiated mesenchymal cell

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Desenvolvimento Ósseo / Condrócitos / Alvo Mecanístico do Complexo 1 de Rapamicina / Proteína 1 do Complexo Esclerose Tuberosa Limite: Animals Idioma: En Revista: Biol Pharm Bull Assunto da revista: BIOQUIMICA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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