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Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
Alsaleh, Ghada; Panse, Isabel; Swadling, Leo; Zhang, Hanlin; Richter, Felix Clemens; Meyer, Alain; Lord, Janet; Barnes, Eleanor; Klenerman, Paul; Green, Christopher; Simon, Anna Katharina.
Afiliação
  • Alsaleh G; The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
  • Panse I; The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
  • Swadling L; Division of Infection and Immunity, University College London, London, United Kingdom.
  • Zhang H; The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
  • Richter FC; The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
  • Meyer A; Fédération de médecine translationnelle Université de Strasbourg, Strasbourg, France.
  • Lord J; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
  • Barnes E; Peter Medawar Building for Pathogen Research,Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Klenerman P; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, United Kingdom.
  • Green C; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom.
  • Simon AK; Peter Medawar Building for Pathogen Research,Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Elife ; 92020 12 15.
Article em En | MEDLINE | ID: mdl-33317695
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Autofagia / Envelhecimento / Espermidina / Linfócitos T CD8-Positivos / Vacinas contra Vírus Sincicial Respiratório Limite: Adult / Aged / Animals / Humans / Middle aged Idioma: En Revista: Elife Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Autofagia / Envelhecimento / Espermidina / Linfócitos T CD8-Positivos / Vacinas contra Vírus Sincicial Respiratório Limite: Adult / Aged / Animals / Humans / Middle aged Idioma: En Revista: Elife Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido